Every ingredient in every N&O LLC product is backed by published, peer-reviewed research. Here is a curated library of that research, organized by condition.
We do not ask you to take our word for it. We ask you to read the research yourself. Every citation on this page links to a peer-reviewed study published in a recognized medical or scientific journal and indexed on PubMed or PubMed Central — the same databases used by clinicians, researchers, and pharmacists worldwide.
Each condition below includes featured clinical studies, plus a live PubMed search link for deeper research into any ingredient or topic.
Prescription GLP-1 medications have transformed weight management — but they are expensive, carry significant side effects, and cause rebound weight gain when discontinued. A growing body of research shows that specific botanical compounds activate many of the same metabolic pathways: GLP-1 secretion, insulin sensitivity, gastric emptying, thermogenesis, and appetite regulation.
Key ingredients studied: Berberine · Ceylon Cinnamon · Fenugreek · Green Tea EGCG · Forskolin · L-Carnitine · Gymnema Sylvestre · Saffron · Ashwagandha · 5-HTP · White Kidney Bean · Grains of Paradise · Capsicum
Randomized, double-blind, placebo-controlled clinical trial. Berberine 500mg three times daily produced 36% remission of metabolic syndrome, significant decreases in waist circumference, systolic blood pressure, triglycerides, and increased insulin sensitivity.
Read the study →Comprehensive literature review through 2025. Demonstrates berberine's multi-target effects on glucose metabolism, insulin signaling, pancreatic beta-cell protection, and induction of GLP-1 secretion — the same pathway prescription GLP-1 agonists act on.
Read the review →Study confirming that berberine metabolites berberrubine and palmatine significantly increase glucose-stimulated GLP-1 secretion from intestinal L-cells — the exact cells that produce the body's natural GLP-1 hormone.
Read the study →Meta-analysis of multiple randomized placebo-controlled trials confirming berberine improves glucose, triglycerides, HDL, insulin resistance, and weight parameters — establishing strong clinical evidence for metabolic applications.
Read the meta-analysis →Cognitive decline begins decades before symptoms appear — as mitochondrial efficiency drops, neuroinflammation rises, and nerve growth factor production slows. The research on medicinal mushrooms and adaptogens demonstrates genuine neuroprotective and neurogenic effects, supporting both daily cognitive function and long-term brain health.
Key ingredients studied: Lion's Mane Mushroom · Reishi · Chaga · Turkey Tail · Cordyceps · Ashwagandha (KSM-66®) · Ginkgo Biloba · Gotu Kola · Turmeric · Matcha Green Tea · Moringa · PurePQQ® · NMN
Comprehensive narrative review of Lion's Mane research. Highlights its capacity to stimulate nerve growth factor (NGF) synthesis — a key molecule in preventing and managing neurodegenerative diseases including Alzheimer's and Parkinson's. Erinacines have demonstrated the ability to cross the blood-brain barrier.
Read the review →Double-blind, placebo-controlled trial in 41 healthy adults. A single 1.8g dose of Lion's Mane produced significantly faster Stroop task performance 60 minutes post-dose. 28-day supplementation showed trends toward reduced subjective stress.
Read the study →Foundational study demonstrating that Lion's Mane aqueous extract combined with nerve growth factor (NGF) produced a 60.6% increase in neurite outgrowth in neuroblastoma-glioma cells — the biological mechanism underlying its cognitive and neuroprotective effects.
Read the study →Double-blind randomized placebo-controlled study. Discusses Lion's Mane's role in monoaminergic pathways, neurogenesis, neurotrophic factor expression, and anti-inflammatory effects via modulation of IL-6, TNF-α, and NF-κB pathways.
Read the study →Current MS disease-modifying therapies (DMTs) reduce relapses and slow lesion formation, but no approved medication directly repairs damaged myelin or restores mitochondrial function in the central nervous system. The research on specific botanicals — curcumin, boswellia, black seed, quercetin — demonstrates meaningful effects on the three core MS mechanisms: neuroinflammation, demyelination, and mitochondrial dysfunction.
Key ingredients studied: Curcumin (95% curcuminoids) · Boswellia Serrata · Black Seed (Nigella sativa) · Quercetin · Vitamin D3 · Vitamin K2 · Lion's Mane · Gotu Kola · NMN · PurePQQ® · CoQ10 Ubiquinol
Randomized controlled trial in 80 active relapsing MS patients, 24-month follow-up. Findings suggested curcumin added to IFN β-1a therapy improved radiological signs of inflammation on MRI, providing early clinical evidence for curcumin's role in MS inflammation management.
Read the clinical trial →Human clinical trial of nanocurcumin in MS patients. Results demonstrated that nanocurcumin inhibits neuroinflammation by modulating Th17 cell function, cytokine expression, and microRNA profiles — addressing core immunological drivers of MS disease progression.
Read the clinical trial →Review detailing curcumin's mechanisms in MS: inhibition of proinflammatory cytokine secretion, modulation of Th17 cell overactivation, suppression of STAT-1 and NF-κB pathways, and protection against oxidative stress. Explains why curcumin is one of the most studied natural compounds in MS research.
Read the review →Comprehensive review of curcumin's downregulation of NF-κB and downstream gene targets including COX-2, TNF-α, IL-1, and IL-6. Establishes the molecular rationale for curcumin's anti-inflammatory effects in MS and related autoimmune neurological diseases.
Read the review →Preclinical study in EAE (experimental autoimmune encephalomyelitis) — the standard animal model for MS. Polymerized nano-curcumin decreased disease scores in both therapeutic and prophylactic administration, with histologically confirmed reduction in demyelination, oxidative stress, and improved myelin repair.
Read the study →Mitochondrial decline is now recognized as a foundational driver of aging and age-related disease. The research on NAD+ precursors (NMN), mitochondrial biogenesis activators (PQQ), and electron transport co-factors (CoQ10 Ubiquinol) shows direct and measurable effects on cellular energy production, DNA repair pathways, and oxidative stress reduction.
Key ingredients studied: NMN (Uthever® Beta-Nicotinamide Mononucleotide) · PurePQQ® (Pyrroloquinoline Quinone) · CoQ10 Ubiquinol · Resveratrol · L-Carnitine
Curated PubMed search of human clinical trials demonstrating NMN's effects on NAD+ levels, insulin sensitivity, muscle function, and cellular aging markers. Research shows NMN supplementation at 250–600 mg/day elevates blood NAD+ concentrations in humans.
Browse current trials →PubMed research collection on PurePQQ®'s mechanism as a mitochondrial biogenesis activator — stimulating the creation of entirely new mitochondria through PGC-1α pathway activation. Studies at the 20 mg daily clinical dose demonstrate measurable effects on cellular energy markers.
Browse current research →Extensive clinical literature on CoQ10 Ubiquinol's effects in cardiovascular health, statin-induced CoQ10 depletion, neurodegenerative disease, and mitochondrial dysfunction. Clinical doses studied from 100 mg to 1,200 mg daily with strong safety profile.
Browse current trials →Women's herbal medicine has centuries of traditional use backed by an increasing body of clinical research — for menstrual health, menopausal transition, uterine health, and hormonal balance. The ingredients in our women's formulas are selected based on published evidence for their specific hormonal pathways.
Key ingredients studied: Evening Primrose Oil · Dong Quai · Red Clover · Black Cohosh · Chasteberry (Vitex) · Red Raspberry Leaf
Curated PubMed collection of clinical trials on black cohosh for vasomotor symptoms (hot flashes), sleep disturbance, and mood changes in perimenopausal and postmenopausal women. Standardized extracts at 40 mg have been studied in multiple RCTs.
Browse current trials →Traditional uterine tonic with emerging modern research on uterine tone, menstrual regulation, and pregnancy support. Long history of use combined with growing scientific interest in its active compounds.
Browse current research →Clinical research on chasteberry's effects on the hypothalamic-pituitary axis, prolactin modulation, and PMS symptom relief. Multiple RCTs support its use at 20–40 mg daily for cyclical symptom management.
Browse current trials →PubMed is the U.S. National Library of Medicine's database of peer-reviewed medical and scientific literature. Every study we cite links to its official PubMed or PubMed Central (PMC) entry. When you click a study, you will see the abstract — a summary of the research methodology, results, and conclusions. Many studies link to the full text, either on PubMed Central (free) or through the publishing journal.
Study types to look for: Randomized controlled trials (RCTs) are the gold standard — they compare an active treatment to a placebo with random assignment. Meta-analyses pool results from multiple RCTs and provide the strongest evidence. Systematic reviews and narrative reviews summarize the existing literature. Preclinical studies (in vitro or animal) suggest mechanisms but do not prove human efficacy alone.
A note on herbal research: Herbal medicine research faces unique challenges that pharmaceutical research does not. Ingredients vary by source, extraction method, and standardization. Study doses may differ from commercial products. We prioritize standardized, branded ingredients (KSM-66®, Uthever®, PurePQQ®, BioPerine®) precisely because their research is reproducible.
Always consult your healthcare provider before starting any supplement regimen, especially if you are taking prescription medications or have a medical condition. Research is the foundation — your clinician is the guide.
Every N&O LLC product page explains exactly what's in the formula and how the research translates into therapeutic dosing.
Explore Protocols Shop All Products*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen, especially if you are taking medications or have a medical condition.